National Institutes of Health

Description

This FOA encourages Research Project Grant (R01) applications from institutions/organizations that propose to study the neuroimmune mechanisms of alcohol-related disorders. Studies using animal models and post-mortem human alcoholic brains suggest that alcohol exposure alters the neuroimmune system in the brain. However, it remains unclear how the altered neuroimmune signaling contributes to brain functional and behavioral changes associated with alcohol dependence. Recent studies reveal that neuroimmune molecules are expressed in neurons and glia, and play an important role in modulating synaptic function, neurodevelopment, and neuroendocrine function. These neuromodulatory properties, together with their essential roles in neuroinflammation, provide a new frame work to understand the role of neuroimmune factors in mediating neuroadaptation and behavioral phenotypes associated with alcohol use disorders. Studies supported by this FOA will provide fundamental insights of neuroimmune mechanisms underlying brain functional and behavioral changes induced by alcohol.

Who can apply

• State governments
• County governments
• City or township governments
• Special district governments
• Independent school districts
• Public and State controlled institutions of higher education
• Native American tribal governments (Federally recognized)
• Public housing authorities / Indian housing authorities
• Native American tribal organizations (other than Federally recognized)
• Nonprofits with 501(c)(3) status (other than higher education)
• Nonprofits without 501(c)(3) status (other than higher education)
• Private institutions of higher education
• For-profit organizations other than small businesses
• Small businesses
• Others

Contact

NIH OER Webmaster<br/>FBOWebmaster@OD.NIH.GOV<br/>
FBOWebmaster@OD.NIH.GOV