National Institutes of Health

Description

This Funding Opportunity Announcement (FOA) solicits U01 applications for a Coordination and Data Management Group (CDMG) as a component of a Consortium to conduct biological analysis of screen-detected, interval-detected, and symptom-detected Cancers.The Consortium will have independent, multi-disciplinary teams to undertake a comprehensive molecular and cellular characterization of tumor tissue, cell, and microenvironment components to distinguish screen-detected early lesions from interval and symptom-detected cancers.Individual research teams will pursue one or more aspects of molecular and cellular analysis of one or more of the specified tumor sites (breast, prostate, lung, melanoma, and pancreas).Use of enabling approaches and technologies will be encouraged to determine both the cellular and molecular phenotypes of early lesions, to assess the degree to which the behavior of these lesions is predictable or stochastic, and to allow better predictions of the fate of early lesions.To achieve the goal of a comprehensive characterization of screen-detected lesions, each research team should include cancer researchers and clinicians with multi-disciplinary expertise.The funded individual research teams are expected to participate in a collaborative Consortium.In addition to individual studies, a major collaborative effort within Consortium will be the establishment of an annotated biospecimen repository of screen-detected lesions and interval cancers.Research teams will also be expected to share results freely within Consortium, and to develop trans-Consortium collaborative projects that make use of the combined expertise and technological capabilities present in all of the teams. The responsibilities of the CDMG will be: (1) coordination of consortium-wide meetings and conferences, and collaborative activities; (2) statistical support and computational analysis; and 3) data management and protocol development for the biorepository.

Who can apply

• State governments
• Public and State controlled institutions of higher education
• Nonprofits with 501(c)(3) status (other than higher education)
• Nonprofits without 501(c)(3) status (other than higher education)
• Private institutions of higher education
• For-profit organizations other than small businesses
• Small businesses
• Others

Contact

NIH OER Webmaster <br/>FBOWebmaster@OD.NIH.GOV <br/>
FBOWebmaster@OD.NIH.GOV