National Institutes of Health

Description

This Funding Opportunity Announcement (FOA) solicits research projects that study the mechanisms of oral immune system plasticity relevant to chronic HIV infection and oral coinfections.In this context, we encourage studies on reversal of immune activation, residual inflammation, immune reconstitution inflammatory syndrome (IRIS), and microbial and by-product translocation.These conditions occur in persons chronically infected with HIV who are treated with combination antiretroviral therapy (cART) and who also experience oral opportunistic infections.The ultimate goals of this FOA are: 1) to gain knowledge regarding the pathogenesis and persistence of these oral conditions; and 2) to guide the development of novel oral immune modulatory therapies that will aid in re-building the oral immune system to reverse these diseases, mitigate their progression, prevent their occurrence, and eliminate persistence of residual HIV and other oral pathogens in reservoirs.

Who can apply

• State governments
• County governments
• City or township governments
• Special district governments
• Independent school districts
• Public and State controlled institutions of higher education
• Native American tribal governments (Federally recognized)
• Public housing authorities / Indian housing authorities
• Native American tribal organizations (other than Federally recognized)
• Nonprofits with 501(c)(3) status (other than higher education)
• Nonprofits without 501(c)(3) status (other than higher education)
• Private institutions of higher education
• For-profit organizations other than small businesses
• Small businesses
• Others

Contact

NIH OER Webmaster<br/>FBOWebmaster@OD.NIH.GOV<br/>
FBOWebmaster@OD.NIH.GOV