Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Therapeutic Agent Characterization and Preclinical Efficacy Studies

Forecasted

National Institutes of Health

Description

The National Institute of Neurological Disorders and Stroke, National Institute of Aging, the NIH Helping to End Addiction Long Term (HEAL) initiative, and other participating ICs seek to support applications to conduct pharmacodynamic, pharmacokinetic, and efficacy studies to demonstrate that the proposed therapeutic agent(s) have sufficient biological activity to warrant further development as therapeutics for disorders or diseases supported by participating ICs or for non-opioid analgesic therapeutics with little or no addiction liability as a part of the NIH HEAL initiative. Therapeutic agents include small molecules or biologics. Efficacy testing can be conducted in validated in vivo models and/or validated New Approach Methodologies (NAMs) as appropriate.Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.

Who can apply

  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Public and State controlled institutions of higher education
  • Native American tribal governments (Federally recognized)
  • Public housing authorities / Indian housing authorities
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Private institutions of higher education
  • For-profit organizations other than small businesses
  • Small businesses
  • Others

Contact


NINDS_IGNITE@nih.gov

Key dates & funding
  • PostedFeb 25, 2026
  • CFDA93.853
Categories

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