National Institutes of Health

Description

The purpose of the Somatic Mosaicism across Human Tissues (SMaHT) Network is to advance the discovery of biological processes and disease mechanisms mediated by somatic mutations in human tissues. Since 2023, the program has generated multi-omic somatic mutation datasets from a standardized set of human tissues spanning all three germ layers. Building on the Stage 1 foundation, the NIH intends to issue a Notice of Funding Opportunity (NOFO) seeking support for Stage 2 through the National Somatic Mosaicism Commons Data Analysis & Organizational Center. The National Somatic Mosaicism Commons Data Analysis & Organizational Center combines data management and analysis with network governance, coordination, outreach, and training. The Center will develop tools and platforms that allow SMaHT Network members and the wider clinical and research communities to investigate and use these complex datasets.The center will be responsible for managing network data and providing access to data analysis tools developed in the program. This will include building the SMaHT data portal, Variant Catalog, variant browser, visualization tools, and analysis-ready releases. The center will also conduct outreach to clinical and research communities and provide training in SMaHT resources.

Who can apply

• State governments
• County governments
• City or township governments
• Special district governments
• Independent school districts
• Public and State controlled institutions of higher education
• Native American tribal governments (Federally recognized)
• Public housing authorities / Indian housing authorities
• Native American tribal organizations (other than Federally recognized)
• Nonprofits with 501(c)(3) status (other than higher education)
• Nonprofits without 501(c)(3) status (other than higher education)
• Private institutions of higher education
• For-profit organizations other than small businesses
• Small businesses
• Others

Contact

smaht@od.nih.gov