National Institutes of Health

Description

Purpose. This FOA solicits grant applications from institutions/organizations to conduct pilot testing of novel candidate biomarkers and technologies that measure biological responses to chemical toxicants and other environmental stressors. Through collaborations with existing human population studies, investigators will conduct a rigorous evaluation of the performance of novel biomarkers and technologies under a range of exposure levels and collection and storage conditions, to establish the potential and feasibility of applying these novel approaches to large-scale epidemiology and gene-environment studies. Applicants will be expected to describe characteristics of their candidate biomarkers or technologies (e.g., laboratory validation studies, limits of detection, and preliminary data from discovery cohort studies) that demonstrate their suitability for further pilot testing. The goal of this 2-year program is to assess the performance (including testing for sensitivity, specificity, reliability and reproducibility) of these novel approaches in independent cohorts. The emphasis of this FOA is the validation of promising biomarkers and technologies; projects to discover and develop new technology and biomarkers of response are not appropriate to this solicitation and will be returned as nonresponsive. Mechanism of Support. This FOA will utilize the R01 award mechanism and runs in parallel with an FOA of similar scientific scope, RFA-ES-10-007, that encourages applications to pilot test and validate new tools for measuring exposure to chemical and lifestyle stressors. Funds Available and Anticipated Number of Awards. NIEHS, NIAAA, and NIDA intend to commit a combined total of $2,555,000 to fund 5 to 6 awards through this FOA.

Who can apply

• State governments
• County governments
• City or township governments
• Special district governments
• Independent school districts
• Public and State controlled institutions of higher education
• Native American tribal governments (Federally recognized)
• Public housing authorities / Indian housing authorities
• Native American tribal organizations (other than Federally recognized)
• Nonprofits with 501(c)(3) status (other than higher education)
• Nonprofits without 501(c)(3) status (other than higher education)
• Private institutions of higher education
• For-profit organizations other than small businesses
• Small businesses
• Others

Contact

NIH OER Webmaster<br/>FBOWebmaster@OD.NIH.GOV<br/>
FBOWebmaster@OD.NIH.GOV