National Institutes of Health

Description

This FOA, issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), solicits applications for clinical studies to investigate strategies that promote the recovery and maintenance of endogenous insulin secretion among individuals who have prediabetes or are early in the course of type 2 diabetes. Specifically, the aim of this initiative is 1) To assess whether short, intensive interventions can substantially improve the pattern and magnitude of the endogenous insulin response, the extent to which recovery is possible and to identify the factors associated with recovery and retention of endogenous insulin secretion, and 2) To determine the duration of the effect and whether this will facilitate achieving better glucose control. In addition, studies may seek to identify biomarkers that will simplify assessment of beta cell function and improve prediction of whether a given individual will respond positively to the intervention. Although each investigator will propose and conduct a unique protocol, collaboration will be required among awardees to establish common definitions, measures and procedures to promote comparisons of data across protocols.

Who can apply

• State governments
• County governments
• City or township governments
• Special district governments
• Independent school districts
• Public and State controlled institutions of higher education
• Native American tribal governments (Federally recognized)
• Public housing authorities / Indian housing authorities
• Native American tribal organizations (other than Federally recognized)
• Nonprofits with 501(c)(3) status (other than higher education)
• Nonprofits without 501(c)(3) status (other than higher education)
• Private institutions of higher education
• For-profit organizations other than small businesses
• Small businesses
• Others

Contact

NIH OER Webmaster<br/>FBOWebmaster@OD.NIH.GOV<br/>
FBOWebmaster@OD.NIH.GOV